Sulbutiamine: A Unique Thiamine Derivative for Cognitive and Neurological Research

At GlobalChemSolutions.com, we supply high-purity research chemicals to laboratories, universities, and institutions conducting advanced scientific investigations. Among our most sought-after compounds in the nootropic and neurochemical research category is Sulbutiamine, a synthetic derivative of vitamin B1 (thiamine) known for its unique neurological properties and enhanced bioavailability.

Originally developed in Japan, Sulbutiamine has become a valuable tool in cognitive enhancement research, central nervous system (CNS) fatigue modeling, and studies exploring the mechanisms of thiamine transport across the blood-brain barrier.

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What is Sulbutiamine?

Sulbutiamine is a lipophilic derivative of thiamine, created by binding two thiamine molecules via a disulfide bridge and adding isobutyryl groups for improved fat solubility. This structural modification significantly enhances its ability to cross the blood-brain barrier, making it a unique model for thiamine-based nootropic and neurological research.

• IUPAC Name: N-[4-[2-[(4-Amino-2-methylpyrimidin-5-yl)methyl-formylamino]ethyldisulfanyl]butyl]-N′-(1,3-thiazol-4-ylmethyl)urea

• Synonyms: Arcalion, Bisbuthiamine

• Molecular Formula: C32H46N8O6S2

• Molar Mass: 678.9 g/mol

• CAS Number: 3286-46-2

• Form: Off-white to yellowish powder

• Purity: ≥98% (HPLC Verified)

• Storage: Keep in a cool, dry, dark place

⚠️ Important: Sulbutiamine is sold strictly for laboratory and analytical research. It is not for human or veterinary use.

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Scientific Relevance of Sulbutiamine

Sulbutiamine offers a unique mechanism of action by enhancing the concentration of thiamine and thiamine phosphate esters in the brain. This makes it highly valuable in the study of memory, fatigue resistance, neurotransmission, and neuroprotection.

Key Research Benefits:

• ✅ Easily crosses the blood-brain barrier

• ✅ Modulates cholinergic and glutamatergic activity

• ✅ Used in fatigue and motivation studies

• ✅ May impact dopaminergic transmission

• ✅ Unique model for synthetic vitamin B1 analogs

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Applications in Scientific Research

1. Cognitive Function and Memory Studies

Sulbutiamine is often included in research protocols examining memory retention, learning efficiency, and executive function. It modulates activity in the prefrontal cortex, a key area for decision-making and focus.

2. Fatigue and Motivation Models

In studies involving asthenia or central fatigue, Sulbutiamine has shown potential in increasing alertness and stamina, making it a suitable compound in fatigue modeling and CNS arousal research.

3. Neurotransmitter Modulation Research

Sulbutiamine has been observed to influence dopamine and glutamate activity, which are critical pathways in mood, motivation, and neuroplasticity. It offers a non-traditional route for studying dopaminergic regulation.

4. Thiamine Transport and Bioavailability Studies

Its enhanced lipophilicity allows Sulbutiamine to serve as a model compound for exploring drug delivery across the blood-brain barrier, especially in relation to other water-soluble B vitamins.

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Why Buy Sulbutiamine from GlobalChemSolutions?

At GlobalChemSolutions, we prioritize purity, compliance, and scientific integrity. Our Sulbutiamine is manufactured under strict quality protocols and is tested to meet ≥98% HPLC-verified purity for accurate and reproducible results.

Our Promise:

• Premium Quality Sulbutiamine for Research Use

• Certificate of Analysis (COA) with Every Batch

• Fast Global Shipping with Discreet Packaging

• Secure Checkout and Data Protection

• Knowledgeable Support for Scientific Inquiries

We provide Sulbutiamine in airtight, light-resistant containers, ensuring long-term stability for laboratory storage.

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Storage & Handling Guidelines

• Store in original packaging in a cool, dry place, away from sunlight.

• Wear PPE (gloves, goggles, lab coat) while handling.

• Avoid ingestion, inhalation, and contact with skin.

• Dispose of any unused product according to local hazardous material regulations.

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Legal Information

Sulbutiamine is unscheduled in most countries and is generally considered legal for scientific research. However, it is the researcher’s responsibility to ensure compliance with local laws and import regulations.

GlobalChemSolutions does not ship to locations where Sulbutiamine is controlled or restricted.

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Final Thoughts

Sulbutiamine stands out as a powerful compound for those researching cognitive enhancement, neurochemical pathways, and central fatigue. With its unique ability to penetrate the brain and modulate neurotransmission, Sulbutiamine opens the door to discoveries in nootropic science and nutritional neuroscience.

Order research-grade Sulbutiamine today from GlobalChemSolutions.com and equip your lab with the tools to drive meaningful scientific progress.