O-DSMT (O-Desmethyltramadol): A Powerful Research Tool in Opioid and Pain Science

At GlobalChemSolutions.com, we specialize in providing premium-quality research chemicals for qualified laboratories, universities, and pharmaceutical research institutions. Among our most requested analytical compounds is O-DSMT, short for O-Desmethyltramadol—a potent active metabolite of tramadol widely used in opioid, analgesic, and neuropharmacological studies.

O-DSMT is known for its high affinity to the μ-opioid receptor, making it an excellent model compound in the study of pain modulation, receptor signaling, addiction models, and central nervous system activity. Researchers value its enhanced potency over its parent compound, allowing detailed observation of opioid pathway mechanisms.

⚠️ Disclaimer: O-DSMT is sold strictly for laboratory research only. It is not for human consumption and should not be used for clinical or veterinary purposes.

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What is O-DSMT?

O-Desmethyltramadol is the main active metabolite of the prescription analgesic tramadol. When tramadol is processed in the human body, O-DSMT is formed via hepatic metabolism. It is significantly more potent at μ-opioid receptors than tramadol itself, and this increased receptor affinity makes it an ideal compound for opioid receptor binding assays, tolerance models, and analgesic pathway studies.

• Chemical Name: O-Desmethyltramadol

• CAS Number: 73986-66-4

• Molecular Formula: C15H23NO2

• Molar Mass: 249.35 g/mol

• Purity: ≥98% (HPLC verified)

• Appearance: White to off-white crystalline powder

• Form: Free base or hydrochloride salt (specify when ordering)

• Storage Conditions: Cool, dry environment, protected from light

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Research Applications of O-DSMT

O-DSMT plays a critical role in opioid research due to its ability to act as a selective μ-opioid receptor agonist. Its applications span pain science, addiction research, receptor pharmacology, and neurotransmitter modulation.

1. Pain Management and Analgesic Research

O-DSMT is commonly used in lab models to investigate the mechanisms of pain relief. Its potent analgesic action allows scientists to study how synthetic opioids interact with nociceptive pathways and CNS receptor sites.

2. Opioid Receptor Binding Studies

Due to its high receptor affinity, O-DSMT is ideal for mapping μ-opioid receptor activation, studying agonist efficacy, and understanding receptor desensitization and internalization.

3. Addiction and Dependence Modeling

Researchers use O-DSMT to examine tolerance, dependence, and reward pathways in addiction science. It’s a key substance in behavioral pharmacology labs studying opioid misuse potential and withdrawal mechanisms.

4. Neurotransmitter and CNS Function Studies

O-DSMT may also influence serotonin and norepinephrine reuptake, making it relevant for dual-mechanism models of neuromodulation and mood-affecting chemical systems.

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Key Features of O-DSMT from GlobalChemSolutions

• ✅ ≥98% Lab-Tested Purity

• ✅ Ideal for pharmacokinetics and opioid research

• ✅ Shipped in protective, airtight packaging

• ✅ Includes Certificate of Analysis (COA) with every order

• ✅ Available in bulk quantities or small batches for flexibility

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Safe Handling Guidelines

• Always wear gloves, goggles, and protective clothing during handling

• Work in a well-ventilated laboratory environment

• Store securely in a cool, dry place

• Dispose of waste according to local safety regulations

• Never ingest or inhale—this substance is not for human use

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Legal and Compliance Notice

O-DSMT may be considered a controlled substance in certain countries or regions. Researchers are responsible for verifying that their use, importation, and handling of O-DSMT complies with local, national, and international regulations.

GlobalChemSolutions.com will not ship O-DSMT to locations where it is restricted or banned.

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Why Buy O-DSMT from GlobalChemSolutions?

GlobalChemSolutions is committed to scientific integrity, purity, and transparency. Our compounds are trusted by researchers around the world for consistent results and accurate experimentation.

We offer:

• Scientifically verified chemical profiles

• Fast, secure, and discreet international shipping

• Safe checkout with multiple payment options

• Expert support from trained professionals

Every batch of O-DSMT is tested for purity, identity, and contaminants, and we ensure reliable, high-quality supply chains for researchers who demand the best.

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Final Thoughts

O-DSMT is a versatile and powerful research compound with wide application in opioid pharmacology, analgesic modeling, and behavioral neuroscience. At GlobalChemSolutions.com, we are proud to support laboratories with high-purity O-DSMT for advanced research needs.

Order now to add this essential tool to your research portfolio—and experience the GlobalChemSolutions difference.