Fluclotizolam: An Overview

Chemical Structure and Composition

Fluclotizolam is a thienotriazolodiazepine derivative with the chemical formula C₁₅H₁₀ClFN₄S. Its IUPAC name is 2-chloro-4-(2-fluorophenyl)-9-methyl-4H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine. The compound features a fused ring system comprising a diazepine ring, a thiophene ring, and a triazole ring, characteristic of thienotriazolodiazepines.

Pharmacological Effects

Fluclotizolam is expected to exhibit sedative-hypnotic effects, similar to other thienotriazolodiazepines like etizolam. These effects are attributed to its interaction with the GABA_A receptor, enhancing the inhibitory neurotransmitter GABA’s activity in the central nervous system. However, due to limited clinical data, the precise pharmacological profile of Fluclotizolam remains under investigation.

Legal Status

The legal status of Fluclotizolam varies by country. In Canada, it is classified as a Schedule IV controlled substance, indicating it has a recognized medical use but with a potential for abuse. In Germany, it is regulated under the New Psychoactive Substances Act (NpSG), allowing its use only for industrial and scientific purposes. In the United Kingdom, Fluclotizolam falls under the Psychoactive Substances Act, prohibiting its production and supply for human consumption.

Availability and Research Use

Fluclotizolam is not approved for medical use and is primarily available as a research chemical. It has been identified in forensic analyses and is sold as a reference material for analytical laboratories. For instance, Cerilliant offers a certified reference material of Fluclotizolam in acetonitrile solution for analytical purposes.

Safety and Toxicology

Due to the lack of comprehensive clinical studies, the safety profile of Fluclotizolam is not well-established. As with other thienotriazolodiazepines, there is a potential for abuse, dependence, and withdrawal symptoms. It is crucial to exercise caution and adhere to safety guidelines when handling or studying this compound.